To what extent do the tools drive the research? If what you have is a really cool hammer, you may well lose interest in everything that doesn’t look like a nail. Steve Blose, co-founder and later CEO of Protein Databases, Inc. of Huntington Station, recalls that by the 1990s, as DNA sequencing became cheaper and more accessible, “if you weren’t doing DNA, you weren’t in the game” as far as drug companies were concerned, even if what you were doing was potentially just as useful, or even more so.